You’ve probably heard about CBD, but did you know it’s being studied as a potential treatment for dementia?
Recent research, including a study published in March 2022 by Semmelweis University and others, has shed light on how CBD might help.
It’s found to protect cells against harmful effects associated with Alzheimer’s disease, promote memory, and even strengthen cell survival.
Some studies even suggest that combining CBD with THC might enhance memory more than using either alone.
But it’s not all clear-cut. Other research, like a 2021 systematic review, shows mixed or limited evidence on CBD’s effectiveness in treating dementia. The world of CBD and dementia is complex, and science is still unraveling the mysteries.
In this article, we’ll navigate these complexities together. We’ll explore the science behind CBD’s potential benefits for dementia and introduce you to the 5 best CBD products that could make a difference in 2023. Ready to dive in? Let’s get started!
Our Process for Selecting the Best CBD for Dementia
Choosing the perfect CBD product isn’t easy, given the sheer number of options available today. But don’t fret – we’re here to help. We’ve meticulously examined each product with a stringent set of criteria to ensure quality, safety, and transparency.
Unwavering Quality Standards
Each CBD product that made our list meets these essentials:
- It’s made with hemp cultivated right here in the U.S., adhering to high agricultural standards.
- It contains no more than 0.3% THC, as verified by its certificate of analysis (COA) – ensuring you don’t get any unwanted psychoactive effects.
- It’s cleared tests for pesticides, heavy metals, and molds, in line with the COA, safeguarding you from harmful contaminants.
- It’s undergone third-party testing by an ISO 17025-compliant lab, assuring an unbiased quality check.
Delving Deeper into the Details
But we didn’t stop at these basics. We delved further to shortlist products with the following factors in mind:
- The potency of each product, because when it comes to CBD, the dosage makes a difference.
- The ingredient list: we favored products with ingredients specifically known for stress relief.
- The company’s certifications and manufacturing processes to ensure the product comes from trusted, responsible sources.
- The reputation of each brand, including customer reviews, giving us a glimpse into real-life user experiences.
- A keen eye for red flags, like unsupported health claims about their products or a history of FDA warning letters.
Through this thorough and methodical approach, we’re confident that the products we’ve selected are of the highest quality.
Why Only Five Products in Our Guide?
In the landscape of CBD, options abound. You might stumble upon guides featuring 15, 20, or even more products. But let’s face it, isn’t that a bit excessive?
We understand that the wide array of choices can be overwhelming. And after analyzing dozens of merchants and hundreds of products on the market, we’ve found that high-quality CBD products are, in essence, pretty similar. Their differences often boil down to nuances in taste, nothing more.
So, we took a different approach. We wanted to curate a concise list that won’t drown you in a sea of seemingly endless choices.
So we’ve handpicked only five products. But make no mistake, these are not just any five products. They’re the cream of the crop, the top dogs, the… well, you get the point.
Every product on this list is of the highest quality and offers the best price-per-milligram ratio.
So you can be confident that you’re not just getting the best CBD – you’re also getting the best value for your money. Because we believe that when it comes to your health and wellness journey, less can truly be more.
Best 5 CBD Products Effective for Dementia
WATER-SOLUBLE CBD DROPS
Meet the WATER-SOLUBLE CBD DROPS, a citrusy blend of broad-spectrum CBD and organic lemon essential oil. What sets it apart? It’s water-soluble, which means faster and more effective absorption. While not directly linked to dementia, the calming properties of CBD might offer relief for stress or anxiety, common in dementia patients. Plus, it’s vegan-friendly and THC-free.
CBD Gummies with Turmeric and Spirulina
Looking for focus and energy? These CBD Gummies with Turmeric and Spirulina might be your answer. They combine CBD’s calming properties with phosphatidylserine (sharp PS) for mental acuity. While not specifically designed for dementia, the focus-enhancing ingredients could potentially aid in memory and mental sharpness, areas often affected by dementia. And they’re organic and vegan!
Calm 330mg CBN CBDV Full Spectrum CBD Oil
Unwind with Calm 330mg CBN CBDV Full Spectrum CBD Oil. This unique blend of CBD, CBN, and CBDV is designed for relaxation. While not directly targeted at dementia, the sedative effects of CBN coupled with CBDV’s mild relaxation might be beneficial for those with dementia experiencing agitation or sleep issues. It’s a natural way to unwind as the day ends.
Multivitamin CBD Gummies For Men
These Multivitamin CBD Gummies for Men are more than just a tasty treat. They blend CBD with essential nutrients, aiming for overall wellness. While not specifically for dementia, the combination of vitamins and CBD’s calming properties might contribute to general well-being, possibly beneficial for those dealing with dementia-related stress. Plus, they’re vegan and gluten-free.
Full Spectrum CBD Softgels Sleep PM
Good sleep is essential, and Full Spectrum CBD Softgels Sleep PM aims to deliver just that. Combining CBD, THC, melatonin, and a special herbal blend, these softgels are designed to help you sleep better. While not directly related to dementia, good sleep is vital for overall health, and these softgels might be helpful for dementia patients struggling with sleep disturbances. Remember, consistency is key!
What the Research Says About CBD and Dementia
Overview of Cannabis including Kampo Medicine and Therapy for Treatment of Dementia: A Review
The study, published in March 2022, provides an overview of the use of cannabis, including Kampo medicine, for the treatment of dementia.
The research was conducted by a team of scientists from various institutions, including Semmelweis University, Daiichi University of Pharmacy, and the Association for Health Economics Research and Social Insurance and Welfare.
The study primarily focuses on the potential of cannabis, especially Cannabidiol (CBD), as a treatment for Alzheimer’s disease (AD). The researchers reviewed several publications related to the use of cannabis for dementia and concluded that CBD could be useful for the treatment and prevention of AD.
For instance, CBD was found to protect PC-12 cells against neurotoxicity and oxidative stress caused by Aβ proteins, which are associated with Alzheimer’s disease. CBD also inhibits acetylcholinesterase to promote memory, stimulates the neurogenesis of the hippocampus, and strengthens cell survival by reducing ROS production and lipid peroxidation.
The study also highlighted that the combination of CBD and Tetrahydrocannabinol (THC) was more effective in memory enhancement than CBD or THC alone. However, the psychotropic activity of THC was also noted. Twelve studies were associated with these findings.
The research also mentioned the potential side effects of long-term marijuana use, which can result in “cannabis psychosis,” characterized by the development of psychotomimetic and psychiatric disorders and mental deficits.
In terms of numbers and facts, the study pointed out the increasing incidence of dementia worldwide, projected to reach 81.1 million by the year 2040. In Japan, the number of dementia patients is expected to reach 7.3 million in 2025 and 10.2 million in 2050, emphasizing the urgent need for innovative strategies for dementia treatment.
In conclusion, the study suggests that CBD, especially in combination with THC, could be a strong candidate as a prophylactic for AD due to its different pharmacological mechanisms and efficacy compared to current drugs.
Cannabis for Symptom Management in Older Adults
The study, conducted in 2019, aimed to understand the effects of medical cannabis on older adults, focusing on conditions relevant to this demographic, such as dementia, chronic pain, and cancer-related symptoms. The researchers used a structured search in PubMed to identify relevant studies, with criteria including a participant population of older adults (65 years or older), a sample size of at least 10 participants, and the inclusion of medical cannabis in the treatment arm of the study. The search identified 888 records, out of which 8 studies met all the inclusion criteria.
When it comes to dementia, the study found that there is limited and mixed evidence on the effectiveness of medical cannabis. The researchers evaluated 6 randomized controlled trials (RCTs) related to dementia and neuropsychiatric symptoms (NPSs), with a total of 117 participants across all RCTs. Significant improvements were reported in only one of these studies, which had a sample size of just 2 participants. In two of the RCTs with the largest sample sizes, no significant reductions were found in NPS based on the Neuropsychiatric Inventory when using oral THC (a component of cannabis) compared with a placebo. Therefore, the study concluded that there isn’t enough quality evidence to suggest any impact on NPS when using medical cannabis.
A Systematic Review of the Effectiveness of Medical Cannabis for Psychiatric, Movement and Neurodegenerative Disorders
The study titled “A Systematic Review of the Effectiveness of Medical Cannabis for Psychiatric, Movement and Neurodegenerative Disorders” was conducted in 2017 by researchers Keane Lim, Yuen Mei See, and Jimmy Lee from the Institute of Mental Health in Singapore. The goal of this study was to evaluate and synthesize the existing evidence on the effectiveness of cannabis and its derivatives, such as THC and cannabidiol (CBD), for treating psychiatric, neurodegenerative, and movement disorders.
To achieve this, the researchers conducted a systematic search of randomized controlled trials (RCTs) using databases like PubMed, Embase, and the Cochrane Central Register of Controlled Trials. They looked for studies involving people of any age and sex diagnosed with conditions like dystonia, Huntington’s disease, Parkinson’s disease, Alzheimer’s disease, dementia, and psychiatric conditions like psychosis, schizophrenia, and anxiety.
The review included any form of cannabis for medical use, whether smoked, natural, synthetic, or a combination of these. The search initially found 931 records, but only 24 reports met the inclusion criteria and were considered for the review.
When it came to the effects of CBD or cannabis on dementia, the study found mixed evidence. Some trials showed positive findings for reducing agitation in Alzheimer’s disease and dementia, but a definitive conclusion on its efficacy could not be drawn.
How effective and safe is medical cannabis as a treatment of mental disorders? A systematic review
The study, published in 2019, is a systematic review that aimed to assess the efficacy and safety of cannabis-based medicines as a treatment for mental disorders. It followed guidelines published by the Centre for Reviews and Dissemination and the Cochrane Collaboration. The study protocol was registered with the Centre for Reviews and Dissemination at the University of European Archives of Psychiatry and Clinical Neuroscience.
The study analyzed a variety of mental disorders, including Alzheimer’s disorder/dementia, substance use disorders, psychoses, and others. It included randomized-controlled trials (RCTs) that assessed these fully diagnosed mental disorders. The study applied a qualitative data synthesis approach due to the high heterogeneity of primary outcome measures in the identified studies, which made no aggregated data analysis possible.
The study included a total of 83 studies, with the number of participants in each study ranging from 10 to 50. The study used a variety of outcome measures, including disorder remission, change in symptom severity, hospitalization, and patient or care person’s perception of improvement.
Regarding the effects of CBD or cannabis on dementia, the study found that THC- and CBD-based medicines, given as an adjunct to pharmaco- and psychotherapy, were associated with improvements of several symptoms of mental disorders, but not with remission. Side effects occurred, but severe adverse effects were mentioned in single cases only.
Cannabinoids for the treatment of dementia
The study, published in 2021, aimed to determine the efficacy and safety of cannabinoids for the treatment of dementia. It was a systematic review that included all randomized controlled trials (RCTs) of cannabinoids for dementia treatment, regardless of age, sex, subtype, or severity of dementia. The study considered cannabinoids administered by any route, dose, or duration, and compared them with placebo, no treatment, or any active control intervention. The search for relevant studies was conducted on July 8, 2021.
The review included four studies with a total of 126 participants, most of whom had Alzheimer’s disease, and a few had vascular or mixed dementia. The studies tested natural delta-9-tetrahydrocannabinol (THC) and two types of synthetic THC analogues (dronabinol and nabilone) over 3 to 14 weeks, with one study reporting adverse events over 70 weeks of follow-up.
The results of the study showed very low-certainty evidence suggesting that there may be little or no clinically important effect of synthetic THC analogue on cognition. Low-certainty evidence also suggested that cannabinoids may have little or no clinically important effect on overall behavioral and psychological symptoms of dementia. Adverse events were reported, but there were no clear differences between groups except for sedation, which was more frequent among participants taking nabilone.
The authors concluded that based on the data from the four small, short, and heterogeneous placebo-controlled trials, they cannot be certain whether cannabinoids have any beneficial or harmful effects on dementia. If there are benefits, the effects may be too small to be clinically meaningful. The study emphasizes the need for adequately powered, methodologically robust trials with longer follow-up to properly assess the effects of cannabinoids in dementia.
How to Shop for CBD for Dementia
Form: What’s Best for Dementia?
Oil: Ideal for Immediate Needs
CBD oil is the best choice for those looking for immediate effects. Its quick absorption can be crucial for sudden anxiety or mood changes common in dementia.
Gummies: Perfect for Sustained Relief
Gummies are excellent for long-lasting effects, providing a steady release over several hours. This slow release can help maintain a calm and consistent mood throughout the day.
Capsules: Convenient but Slower to Act
Capsules are convenient and mess-free but take longer to kick in. They might not be the best choice for immediate relief but can be suitable for routine supplementation.
Types: What’s the Best Choice for Dementia?
Full-Spectrum: Comprehensive Benefits
Full-spectrum CBD oil, with its entourage effect, is the best option for dementia. It offers a synergistic benefit from all the compounds in the cannabis plant, enhancing its medicinal properties.
Broad-Spectrum: A THC-Free Alternative
Broad-spectrum can be a good alternative if THC sensitivity is a concern, offering some benefits of the entourage effect without THC.
Isolate: Limited Benefits
Isolate might not be the best choice for dementia, as it lacks the full range of beneficial compounds found in full or broad-spectrum options.
Potency: What Strength is Best for Dementia?
High-Potency (1,000 mg): For Severe Symptoms
High-potency CBD oil is best suited for severe symptoms like sleep issues, significant anxiety, or depression often associated with dementia.
Mid-Potency (600 mg): For Moderate Needs
Mid-potency can be a good option for moderate stress and discomfort, common in dementia care.
Low-Potency (300 mg): For General Wellness
Low-potency might be suitable for general wellness and mild stress reduction but might not be sufficient for more pronounced dementia-related symptoms.
How does CBD affect the brain?
CBD can alter brain signaling through the endocannabinoid system. It may change how receptors respond to neurotransmitters like serotonin. CBD also affects areas involved in memory, fear, pleasure, and pain perception. More research is still needed on how CBD fully interacts with the brain.
Can CBD help dementia and memory loss?
A few studies suggest CBD may potentially slow memory loss related to Alzheimer’s disease. It may also help manage dementia symptoms like agitation or anxiety. However, more clinical trials in humans are needed to confirm CBD’s efficacy. Consult a doctor before trying CBD.
Is CBD safe for the brain?
Most evidence shows properly dosed CBD is well tolerated by the brain and has no toxic effects. Side effects can include fatigue or sedation. Very high doses may affect cognition temporarily. More long-term research is still needed, especially on heavy usage.
How much CBD should I take for brain health?
There’s no standard dose of CBD for brain health yet. In studies related to dementia and epilepsy, doses of 20-1500 mg daily were used. It’s best to start low at around 10-20 mg and increase slowly over weeks for the desired effect. Always consult a doctor.
How long does CBD stay in your system?
CBD can stay in your system for 2 to 5 days on average, but this varies widely. The dose, frequency, and delivery method all impact how long CBD remains in the brain and body. Trace amounts may be detectable for over a week in some cases.
What’s the best way to take CBD for the brain?
Sublingual oils, sprays, or tinctures may work fastest since they enter the bloodstream quickly. However, capsules, edibles, vapes, and topicals can also effectively deliver CBD. There is no single best administration method.
Can CBD help anxiety and depression?
Early research shows promise for CBD improving symptoms of anxiety and depression, when used alongside prescribed medications and professional treatment. However, more clinical studies are still needed. Do not stop any medications without consulting your doctor.
Does CBD help seizures and epilepsy?
Strong evidence from trials and research studies shows CBD can significantly reduce seizure frequency for some epilepsy patients. However, results vary by condition. Only use CBD for seizures under medical supervision.
Is CBD addictive?
Unlike THC and marijuana, CBD does not appear to have any addictive potential according to current research. No physical dependence or withdrawal effects have been linked to CBD use. However, more clinical studies confirming the safety long-term are still needed.
Are there drug interactions with CBD?
CBD can potentially interact with many common medications metabolized through the liver’s cytochrome P450 enzyme system. These include certain antidepressants and opioids. Discuss using CBD with your doctor and monitor side effects. Adjust doses as needed.