Synthetix 5 Synthetic Urine Review

Daniel Miller
By Daniel Miller

Ph.D Pharmacology, Drug Testing Specialist

Updated: 2025 Mar 24

Today, I’ll be reviewing Synthetix5 ( Synthetics 5), a premixed synthetic urine designed to mimic human urine. In this review, I’ll unbox the kit, discuss its advantages and disadvantages, and show you how to use it.

Synthetix5 is a synthetic urine product marketed for various legitimate purposes such as calibrating and testing laboratory equipment, costume play, fetish activities, and product testing for items like sanitary pads and diapers. As with all synthetic urines, its effectiveness depends on the quality of its formulation and ease of use.

S5 synthetix5 box

Pros

  • Convenient flip-up spout cap making dispensing clean and easy
  • Generous 3oz quantity sufficient for two separate uses
  • Affordable price point compared to premium synthetic urine products

Cons

  • Regular heat pad issues – can potentially overheat the urine and may cause skin burns if not monitored properly
  • Oversized heat pad – the size may interfere with accurate temperature readings
  • Limited heating options – includes just one heat pad despite having enough urine for two uses
  • Unreliable temperature strip – temperature readings may be inaccurate

What’s in the Kit

Let’s unbox the Synthetix5 kit and examine what’s included:

synthetix 5 contents

The Urine

The urine itself is of regular quality, which is adequate if you need to test absorbent products like diapers or use it for recreational purposes. However, if you’re looking to calibrate sensitive laboratory equipment, it may not be suitable.

As I’ve mentioned in my previous review of best synthetic urines, lower-quality, inexpensive synthetic urines often don’t fully replicate the complete chemical formula of human urine. This means they might be identified as synthetic by specialized testing methods. For professional applications, I typically recommend avoiding budget options.

The color of Synthetix5 is a realistic yellow that closely resembles authentic human urine. This is important for visual authenticity in various applications.

synthetix 5 urine

The kit contains 3 fluid ounces of synthetic urine, providing enough volume for two separate uses, which adds to its value.

Interestingly, the shelf life isn’t clearly stated on the packaging. Most synthetic urine products typically have a shelf life of approximately 2 years when stored properly.

If you plan to use the product twice, proper storage of the remaining urine is critical. After opening the bottle, you should freeze any unused portion, as bacteria can begin to grow at room temperature, potentially compromising the formula’s stability and effectiveness. Research has shown that bacterial contamination can alter the chemical composition of urine samples within hours at room temperature.

The Bottle

The Synthetix5 comes in a flat bottle design, which is advantageous if you’re planning to use it for pranks or recreational activities. This flat profile makes it easier to conceal compared to round bottles offered by some competitors.

While the flat design is good, I personally prefer belt-attached systems for pranks as they offer greater convenience and hands-free operation.

The bottle features a built-in temperature strip, which should theoretically allow you to monitor the urine temperature easily. However, in my testing, I found significant accuracy issues with this component.

When I measured the actual temperature using a digital thermometer showing 91.2°F, the temperature strip indicated somewhere between 96-98°F – a concerning discrepancy of approximately 5-7 degrees.

synthetix 5 synthetic urine temperature strip check

Additionally, the temperature indicator on the strip is notably faded and difficult to read, which could lead to misinterpretation even if it were accurate. For accurate temperature verification, I always recommend using a digital thermometer rather than relying solely on the included strip .

The Cap

One of the standout features of the Synthetix5 is its flip-up spout cap design. This is particularly beneficial in situations where you might be nervous or in a hurry, as traditional screw caps can be challenging to manage and risk spillage.

The flip-up mechanism allows for single-finger operation, making dispensing clean and straightforward. I was pleased to find that despite this convenience, the cap is sufficiently rigid and requires deliberate pressure to open, preventing accidental leaks if carried in a pocket.

Heating Methods

The Synthetix5 includes a heating pad as its primary warming method. While heating pads are indeed the most common approach to maintaining synthetic urine at the right temperature, I noticed several issues with this particular implementation.

First, the kit only includes a single heating pad despite containing enough urine for two separate applications. This inconsistency means you can only properly use the kit once, or you’ll need to purchase additional heating pads separately for a second use.

synthetix 5 heat pad

The heating pad included is unusually large, presumably designed to wrap around the entire bottle. While this approach might warm the urine faster, it presents several significant drawbacks:

  1. Risk of skin burns: If concealed against your body, the oversized pad increases contact with skin, potentially causing uncomfortable burns. Research has shown that prolonged exposure to heating pads can cause first and second-degree burns when in direct contact with skin [2].
  2. Temperature reading interference: Proper technique requires placing the heating pad on the opposite side from the temperature strip. With this oversized pad, it’s nearly impossible to avoid contact with the temperature strip, which leads to inaccurate readings.
  3. Excessive heat production: This pad is a standard hand/foot warmer designed for severe weather conditions and can reach temperatures up to 165°F according to its packaging. This is significantly higher than needed and risks overheating the urine.

Overheating can potentially alter the chemical composition of the synthetic urine, particularly problematic if you’re using it for laboratory equipment calibration. While temporary overheating might not permanently damage the formula, cooling it down within time constraints could prove challenging.

On the positive side, the heating pad does feature an adhesive surface for easy attachment to the bottle, eliminating the need for rubber bands or other fasteners. According to its description, it can maintain warmth for up to 8 hours, though I would conservatively estimate 6 hours of reliable heat.

The pad requires approximately one hour to warm the urine to 100°F. If you need faster heating, microwave warming (following specific instructions) would be necessary.

How to Use Synthetix5

The Synthetix5 kit includes printed instructions on the box, but I’ll walk you through the proper usage process step by step:

synthetix5 instructions

Preparation Instructions

  1. Remove the bottle cap: Take off the top of the bottle to prepare for heating.
  2. Microwave heating: Place the uncapped urine bottle in the microwave for exactly 15 seconds.
    • Important warning: Never exceed 15 seconds of microwave heating as this could damage the synthetic formula or potentially cause the bottle to rupture.
  3. Temperature verification: After heating, check the temperature strip. The ideal temperature range is between 90-100°F.
  4. Temperature adjustment: If the temperature reading is outside the recommended range after the initial check, repeat the heating procedure carefully.
  5. Overheating signs: If no reading appears on the temperature strip but the bottle feels warm to the touch, this indicates the urine has been overheated and needs to cool down before use.

Assembly and Use

  1. Replace cap: Securely attach the flip-up spout cap to the bottle.
  2. Prepare heating pad: Open the heating pad package and remove the covering to activate it.
  3. Attach heating pad: Apply the self-adhesive heating pad to the bottle on the side opposite from the temperature strip. This positioning is crucial to prevent false temperature readings.
  4. Storage position: When concealing the bottle, avoid direct contact between the heating pad and your skin, as the high temperatures can cause burns. Research has shown that heating pads can reach temperatures that may cause first-degree burns with prolonged contact [1].
  5. Dispensing: When ready to use, simply remove the bottle, open the flip-up spout cap with one finger, and pour the required amount of synthetic urine.

According to laboratory practice standards, the timing of the temperature check is critical, as synthetic formulas can lose heat rapidly once removed from their heating source.

Conclusion

Synthetix5 is a basic synthetic urine kit designed for single use, despite containing enough formula for two applications. Due to its affordable price point, it’s suitable for recreational purposes like pranks or fetish activities.

However, if you’re looking for a product to calibrate or test laboratory equipment, you might want to consider more reliable options with better temperature control mechanisms and more accurate chemical formulations.

The temperature strip inaccuracies and heating pad issues I’ve identified make this product less than ideal for precision applications.

Disclaimer

Our synthetic urine products are intended solely for legitimate purposes, including laboratory equipment calibration, fetish activities, testing absorbent products like diapers and sanitary pads, and educational demonstrations.

We do not condone or promote the use of synthetic urine to pass drug tests. Attempting to falsify or circumvent drug screening procedures may be illegal in many jurisdictions and could result in serious legal consequences.

Disclosure Statement

We have no financial relationship or affiliation with any synthetic urine manufacturers. Our reviews are based on independent testing and professional assessment. We do not receive compensation, products, or incentives from manufacturers in exchange for reviews.

All opinions expressed are solely intended to provide unbiased information for those considering these products for lawful and ethical purposes.